Functional roles in cell signaling of adaptor protein TRADD from a structural perspective
نویسندگان
چکیده
منابع مشابه
The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling.
TNFR-associated death domain protein (TRADD) is a key effector protein of TNFR1 signaling. However, the role of TRADD in other death receptor (DR) signaling pathways, including DR3, has not been completely characterized. Previous studies using overexpression systems suggested that TRADD is recruited to the DR3 complex in response to the DR3 ligand, TNF-like ligand 1A (TL1A), indicating a possib...
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TRAF proteins are major mediators for the cell activation, cell survival, and antiapoptotic functions of the TNF receptor superfamily. They can be recruited to activated TNF receptors either by direct interactions with the receptors or indirectly via the adaptor protein TRADD. We now report the structure of the TRADD-TRAF2 complex, which is highly distinct from receptor-TRAF2 interactions. This...
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ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2020
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2020.10.008